Partition ratio (LogD)





Partition ratio (or partition coefficient) is a ratio of drug concentration in two immiscible solvents, typically water and octanol. It is a measure of hydrophobic/hydrophilic properties of a given molecule.
The partition ratio will be performed using the shake-flask method, which consists of dissolving some of the solute of interest in a volume of octanol and water, then measuring the concentration of the solute in each solvent, by using UV/VIS spectroscopy.